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The Netherlands Journal of Medicine Jun 2013¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸FDG-PET) scintigraphy is a useful imaging technique in the evaluation of metastasised thyroid carcinoma....
¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸FDG-PET) scintigraphy is a useful imaging technique in the evaluation of metastasised thyroid carcinoma. Administration of recombinant human thyrotropin (rhTSH, Thyrogen®) increases the diagnostic yield of this procedure. Here we present a 64-year-old male who was followed for Hürthle cell carcinoma of the thyroid with several intrapulmonary metastases. He developed sudden complaints of neck pain following rhTSH administration as part of the routine preparation for a diagnostic ¹⁸FDG-PET÷CT procedure. This investigation subsequently revealed a previously undetected metastatic lesion in the first cervical vertebra, with no signs of spinal cord compression. Treatment with a nonsteroidal anti-inflammatory drug reduced the symptoms sufficiently, and a few weeks later the neurosurgeon performed a complete resection of the metastasis. It is likely that the symptoms were caused by oedema and÷or increased blood flow to the lesion. Physicians should be aware that rhTSH administration to patients with disseminated thyroid carcinoma may lead to sudden onset of symptoms caused by previously occult metastases.
Topics: Adenocarcinoma, Follicular; Adenoma, Oxyphilic; Cervical Vertebrae; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Male; Middle Aged; Neck Pain; Positron-Emission Tomography; Radiopharmaceuticals; Spinal Neoplasms; Thyroid Neoplasms; Thyrotropin Alfa
PubMed: 23799312
DOI: No ID Found -
Revista Medica de Chile Dec 2018We report a 72-years-old male patient with extensive differentiated thyroid cancer (DTC), who required a tracheostomy and gastrostomy. Considering his clinical...
We report a 72-years-old male patient with extensive differentiated thyroid cancer (DTC), who required a tracheostomy and gastrostomy. Considering his clinical condition, risk of aspiration and management of the ostomies, radioiodine (131I) was administered intravenously, using recombinant human thyrotropin (rhTSH) and levothyroxine. The procedure was successful, both clinically and in terms of radioprotection.
Topics: Administration, Intravenous; Aged; Antineoplastic Agents; Gastrostomy; Humans; Iodine Radioisotopes; Male; Radionuclide Imaging; Thyroid Cancer, Papillary; Thyroid Neoplasms; Thyrotropin Alfa; Thyroxine; Tracheostomy; Treatment Outcome
PubMed: 30724989
DOI: 10.4067/S0034-98872018001001220 -
Revista Peruana de Medicina... Jun 2011A 43 year old man presented with asymptomatic elevation of alanine aminotransferase (ALT) and no relevant past history. The patient denied being a chronic alcohol...
A 43 year old man presented with asymptomatic elevation of alanine aminotransferase (ALT) and no relevant past history. The patient denied being a chronic alcohol drinker. Work-up revealed an active hepatitis C, and liver biopsy showed active inflammation. Treatment was started with interferon-alfa and ribavirin. During the 48 weeks of treatment, the patient developed positive thyroid antibodies with varying level of thyrotropin (TSH) and thyroid hormones. At follow-up after treatment, the patient continued with hyperthyroidism due to Graves' disease. Autoimmune thyroiditis is a common complication of using interferon in patients with hepatitis C. In some cases, it is presented as hyperthyroidism because of Graves' disease. Thyroid function and thyroid antibodies should be evaluated before and during treatment with interferon.
Topics: Adult; Hepatitis C; Humans; Interferon-alpha; Male; Thyroiditis, Autoimmune
PubMed: 21845321
DOI: 10.1590/s1726-46342011000200028 -
Archives of Endocrinology and Metabolism Feb 2016This prospective study evaluated the recurrence rate in low-risk patients with papillary thyroid cancer (PTC) who presented slightly elevated thyroglobulin (Tg) after...
OBJECTIVE
This prospective study evaluated the recurrence rate in low-risk patients with papillary thyroid cancer (PTC) who presented slightly elevated thyroglobulin (Tg) after thyroidectomy and who did not undergo ablation with131I.
SUBJECTS AND METHODS
The study included 53 low-risk patients (nonaggressive histology; pT1b-3, cN0pNx, M0) with slightly elevated Tg after thyroidectomy (> 1 ng/mL, but ≤ 5 ng/mL after levothyroxine withdrawal or ≤ 2 ng/mL after recombinant human TSH).
RESULTS
The time of follow-up ranged from 36 to 96 months. Lymph node metastases were detected in only one patient (1.9%). Fifty-two patients continued to present negative neck ultrasound. None of these patients without apparent disease presented an increase in Tg.
CONCLUSIONS
Low-risk patients with PTC who present slightly elevated Tg after thyroidectomy do not require ablation with 131I.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma; Carcinoma, Papillary; Female; Follow-Up Studies; Humans; Iodine Radioisotopes; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies; Thyroglobulin; Thyroid Cancer, Papillary; Thyroid Neoplasms; Thyroidectomy; Thyrotropin Alfa; Young Adult
PubMed: 26909477
DOI: 10.1590/2359-3997000000158